T53S (p.Thr53Ser) variant of TNFAIP3 (P21580)
T53S (p.Thr53Ser) in TNFAIP3 (P21580) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as uncertain significance in the context of not provided. The available variant effect predictions contribute to a CATVariant prioritization score of 0.27 / 1. The record also includes structural context.
T53S (p.Thr53Ser) variant details
- p.Thr53Ser
- rs2114459340
- ClinGen CA365780519
- ClinVar RCV002846628
- Uncertain significance
- not provided
- Missense
- Variant Prioritization Score for Impact Estimate 0.271
- AlphaMissense 0.25
- MetaLR 0.01
- MetaSVM -1.01
- PolyPhen-2 0.01
- SIFT 0.30
- EVE 0.12
- ClinVar: Uncertain significance (not provided)
- EBI: Variant of uncertain significance
- UniProt: Uncertain significance
- Structural context available