T33A (p.Thr33Ala) variant of TNFAIP3 (P21580)
T33A (p.Thr33Ala) in TNFAIP3 (P21580) is a missense change. Clinical records from ClinVar and UniProt describe it as uncertain significance in the context of not provided. The available variant effect predictions contribute to a CATVariant prioritization score of 0.31 / 1. The record also includes population frequency data and structural context.
T33A (p.Thr33Ala) variant details
- p.Thr33Ala
- ExAC rs746536779
- gnomAD rs746536779
- Uncertain significance
- not provided
- Missense
- Variant Prioritization Score for Impact Estimate 0.308
- MetaLR 0.01
- MetaSVM -1.02
- CADD 17.10
- PolyPhen-2 0.00
- SIFT 0.19
- ClinVar: Uncertain significance (not provided)
- UniProt: Uncertain significance
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available