T25I (p.Thr25Ile) variant of TNFAIP3 (P21580)
T25I (p.Thr25Ile) in TNFAIP3 (P21580) is a missense change. Clinical records from EBI and UniProt describe it as uncertain significance. The available variant effect predictions contribute to a CATVariant prioritization score of 0.43 / 1. The record also includes population frequency data and structural context.
T25I (p.Thr25Ile) variant details
- p.Thr25Ile
- rs757112036
- ClinGen CA4019341
- cosmic curated COSV10586
- ClinVar RCV003107073
- Uncertain significance
- Missense
- Variant Prioritization Score for Impact Estimate 0.433
- MetaLR 0.02
- MetaSVM -1.03
- CADD 17.20
- PolyPhen-2 0.07
- SIFT 1.00
- EBI: Variant of uncertain significance
- UniProt: Uncertain significance
- Most common in the East Asian population (allele frequency 0.00019)
- Structural context available