R22W (p.Arg22Trp) variant of TNFAIP3 (P21580)
R22W (p.Arg22Trp) in TNFAIP3 (P21580) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.43 / 1. The record also includes population frequency data and structural context.
R22W (p.Arg22Trp) variant details
- p.Arg22Trp
- TOPMed rs1170624868
- Missense
- Variant Prioritization Score for Impact Estimate 0.431
- MetaLR 0.10
- MetaSVM -0.88
- CADD 23.60
- PolyPhen-2 1.00
- SIFT 0.05
- Most common in the African/African-American population (allele frequency 3e-05)
- Structural context available