V77I (p.Val77Ile) variant of TNF (Tumor necrosis factor)
V77I (p.Val77Ile) in TNF (Tumor necrosis factor) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.29 / 1. The record also includes population frequency data, published literature, and structural context.
V77I (p.Val77Ile) variant details
- p.Val77Ile
- gnomAD 6-31576576-G-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.29
- REVEL 0.13
- CADD 14.90
- PolyPhen-2 0.02
- SIFT 0.12
- Most common in the South Asian population (allele frequency 1.2e-05)
- Structural context available
- Literature evidence available