V41M (p.Val41Met) variant of TNF (Tumor necrosis factor)
V41M (p.Val41Met) in TNF (Tumor necrosis factor) is a missense change. Clinical records from EBI and UniProt describe it as uncertain significance. The available variant effect predictions contribute to a CATVariant prioritization score of 0.45 / 1. The record also includes population frequency data and structural context.
V41M (p.Val41Met) variant details
- p.Val41Met
- 1000Genomes rs558678940
- ExAC rs558678940
- TOPMed rs558678940
- gnomAD rs558678940
- Uncertain significance
- Missense
- Variant Prioritization Score for Impact Estimate 0.446
- REVEL 0.39
- CADD 23.50
- PolyPhen-2 0.78
- SIFT 0.02
- EBI: Variant of uncertain significance
- UniProt: Uncertain significance
- Most common in the 1KG:GWD population (allele frequency 0.0043)
- Structural context available