V41L (p.Val41Leu) variant of TNF (Tumor necrosis factor)
V41L (p.Val41Leu) in TNF (Tumor necrosis factor) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as uncertain significance in the context of not specified. The available variant effect predictions contribute to a CATVariant prioritization score of 0.25 / 1. The record also includes population frequency data and structural context.
V41L (p.Val41Leu) variant details
- p.Val41Leu
- rs558678940
- 1000Genomes rs558678940
- ExAC rs558678940
- TOPMed rs558678940
- Uncertain significance
- not specified
- Missense
- Variant Prioritization Score for Impact Estimate 0.252
- REVEL 0.12
- CADD 12.90
- PolyPhen-2 0.02
- SIFT 1.00
- ClinVar: Uncertain significance (not specified)
- EBI: Variant of uncertain significance
- UniProt: Uncertain significance
- Most common in the Finnish in Finland (FIN) population (allele frequency 3.8e-05)
- Structural context available