V41A (p.Val41Ala) variant of TNF (Tumor necrosis factor)
V41A (p.Val41Ala) in TNF (Tumor necrosis factor) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.46 / 1. The record also includes population frequency data, published literature, and structural context.
V41A (p.Val41Ala) variant details
- p.Val41Ala
- gnomAD 6-31575863-T-C
- Missense
- Variant Prioritization Score for Impact Estimate 0.464
- REVEL 0.42
- CADD 24.00
- PolyPhen-2 0.49
- SIFT 0.01
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available
- Literature evidence available