V10M (p.Val10Met) variant of TNF (Tumor necrosis factor)
V10M (p.Val10Met) in TNF (Tumor necrosis factor) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.47 / 1. The record also includes population frequency data and structural context.
V10M (p.Val10Met) variant details
- p.Val10Met
- rs759696973
- ExAC rs759696973
- TOPMed rs759696973
- gnomAD rs759696973
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.474
- REVEL 0.41
- CADD 26.50
- PolyPhen-2 0.87
- SIFT 0.01
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the HGDP:COLOMBIAN population (allele frequency 0.17)
- Structural context available