T83N (p.Thr83Asn) variant of TNF (Tumor necrosis factor)
T83N (p.Thr83Asn) in TNF (Tumor necrosis factor) is a missense change. Clinical records from ClinVar and UniProt describe it as uncertain significance in the context of Inherited susceptibility to asthma; Migraine with or without aura, susceptibilit. The available variant effect predictions contribute to a CATVariant prioritization score of 0.16 / 1. The record also includes population frequency data and structural context.
T83N (p.Thr83Asn) variant details
- p.Thr83Asn
- TOPMed rs897338372
- gnomAD rs897338372
- Uncertain significance
- Inherited susceptibility to asthma; Migraine with or without aura, susceptibilit
- Missense
- Variant Prioritization Score for Impact Estimate 0.164
- REVEL 0.14
- CADD 3.45
- PolyPhen-2 0.00
- SIFT 0.70
- ClinVar: Uncertain significance (Inherited susceptibility to asthma; Migraine with or without aur)
- UniProt: Uncertain significance
- Most common in the REMAINING population (allele frequency 6.6e-05)
- Structural context available