T46M (p.Thr46Met) variant of TNF (Tumor necrosis factor)
T46M (p.Thr46Met) in TNF (Tumor necrosis factor) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.15 / 1. The record also includes population frequency data and structural context.
T46M (p.Thr46Met) variant details
- p.Thr46Met
- 1000Genomes rs200241887
- ExAC rs200241887
- TOPMed rs200241887
- gnomAD rs200241887
- Missense
- Variant Prioritization Score for Impact Estimate 0.154
- REVEL 0.12
- CADD 8.75
- PolyPhen-2 0.04
- SIFT 0.10
- Most common in the 1KG:PUR population (allele frequency 0.0051)
- Structural context available