T46K (p.Thr46Lys) variant of TNF (Tumor necrosis factor)
T46K (p.Thr46Lys) in TNF (Tumor necrosis factor) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.31 / 1. The record also includes population frequency data, published literature, and structural context.
T46K (p.Thr46Lys) variant details
- p.Thr46Lys
- gnomAD 6-31575878-C-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.314
- REVEL 0.37
- CADD 14.30
- PolyPhen-2 0.22
- SIFT 0.02
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available
- Literature evidence available