R8W (p.Arg8Trp) variant of TNF (Tumor necrosis factor)
R8W (p.Arg8Trp) in TNF (Tumor necrosis factor) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.57 / 1. The record also includes population frequency data and structural context.
R8W (p.Arg8Trp) variant details
- p.Arg8Trp
- ESP rs374531985
- ExAC rs374531985
- TOPMed rs374531985
- gnomAD rs374531985
- Missense
- Variant Prioritization Score for Impact Estimate 0.567
- REVEL 0.48
- CADD 25.70
- PolyPhen-2 0.77
- SIFT 0.06
- Most common in the South Asian population (allele frequency 8.3e-05)
- Structural context available