R78S (p.Arg78Ser) variant of TNF (Tumor necrosis factor)
R78S (p.Arg78Ser) in TNF (Tumor necrosis factor) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.43 / 1. The record also includes population frequency data, published literature, and structural context.
R78S (p.Arg78Ser) variant details
- p.Arg78Ser
- gnomAD 6-31576768-A-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.429
- REVEL 0.36
- CADD 23.00
- PolyPhen-2 0.14
- SIFT 0.22
- Most common in the Non-Finnish European population (allele frequency 1.8e-06)
- Structural context available
- Literature evidence available