R60S (p.Arg60Ser) variant of TNF (Tumor necrosis factor)
R60S (p.Arg60Ser) in TNF (Tumor necrosis factor) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.24 / 1. The record also includes population frequency data, published literature, and structural context.
R60S (p.Arg60Ser) variant details
- p.Arg60Ser
- gnomAD 6-31575921-G-C
- Missense
- Variant Prioritization Score for Impact Estimate 0.243
- REVEL 0.15
- CADD 19.30
- PolyPhen-2 0.04
- SIFT 0.27
- Most common in the Non-Finnish European population (allele frequency 9.3e-07)
- Structural context available
- Literature evidence available