R29W (p.Arg29Trp) variant of TNF (Tumor necrosis factor)
R29W (p.Arg29Trp) in TNF (Tumor necrosis factor) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.36 / 1. The record also includes population frequency data and structural context.
R29W (p.Arg29Trp) variant details
- p.Arg29Trp
- rs1260793650
- gnomAD rs1260793650
- NCI-TCGA Cosmic COSV1014
- NCI-TCGA Cosmic COSV6930
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.355
- REVEL 0.33
- CADD 22.50
- PolyPhen-2 0.94
- SIFT 0.02
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 1.5e-05)
- Structural context available