P84L (p.Pro84Leu) variant of TNF (Tumor necrosis factor)
P84L (p.Pro84Leu) in TNF (Tumor necrosis factor) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as benign/likely benign in the context of not provided. The available variant effect predictions contribute to a CATVariant prioritization score of 0.22 / 1. The record also includes population frequency data, published literature, and structural context.
P84L (p.Pro84Leu) variant details
- p.Pro84Leu
- rs4645843
- 1000Genomes rs4645843
- ESP rs4645843
- ExAC rs4645843
- Benign/Likely benign
- not provided
- Missense
- Variant Prioritization Score for Impact Estimate 0.225
- REVEL 0.19
- CADD 14.30
- PolyPhen-2 0.01
- SIFT 0.27
- ClinVar: Benign/Likely benign (not provided)
- EBI: Benign (in dbSNP:rs4645843)
- UniProt: Benign (in dbSNP:rs4645843)
- Most common in the HGDP:OROQEN population (allele frequency 0.062)
- Structural context available
- Literature evidence available