P58L (p.Pro58Leu) variant of TNF (Tumor necrosis factor)
P58L (p.Pro58Leu) in TNF (Tumor necrosis factor) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.67 / 1. The record also includes population frequency data, published literature, and structural context.
P58L (p.Pro58Leu) variant details
- p.Pro58Leu
- gnomAD 6-31575914-C-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.665
- REVEL 0.58
- CADD 25.20
- PolyPhen-2 0.99
- SIFT 0.06
- Population evidence available
- Structural context available
- Literature evidence available