P24L (p.Pro24Leu) variant of TNF (Tumor necrosis factor)
P24L (p.Pro24Leu) in TNF (Tumor necrosis factor) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.23 / 1. The record also includes population frequency data, published literature, and structural context.
P24L (p.Pro24Leu) variant details
- p.Pro24Leu
- gnomAD 6-31575812-C-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.235
- REVEL 0.11
- CADD 19.80
- PolyPhen-2 0.02
- SIFT 0.12
- Most common in the Ashkenazi Jewish population (allele frequency 3.8e-05)
- Structural context available
- Literature evidence available