P24A (p.Pro24Ala) variant of TNF (Tumor necrosis factor)
P24A (p.Pro24Ala) in TNF (Tumor necrosis factor) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; high impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.14 / 1. The record also includes population frequency data and structural context.
P24A (p.Pro24Ala) variant details
- p.Pro24Ala
- ExAC rs754639425
- TOPMed rs754639425
- gnomAD rs754639425
- NCI-TCGA TCGA novel
- Variant assessed as somatic; high impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.142
- REVEL 0.07
- CADD 13.00
- PolyPhen-2 0.01
- SIFT 0.29
- UniProt: Variant assessed as somatic; high impact.
- Most common in the South Asian population (allele frequency 2.3e-05)
- Structural context available