P18T (p.Pro18Thr) variant of TNF (Tumor necrosis factor)
P18T (p.Pro18Thr) in TNF (Tumor necrosis factor) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.18 / 1. The record also includes population frequency data, published literature, and structural context.
P18T (p.Pro18Thr) variant details
- p.Pro18Thr
- gnomAD 6-31575793-C-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.178
- REVEL 0.16
- CADD 5.97
- PolyPhen-2 0.07
- SIFT 0.41
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available
- Literature evidence available