L69P (p.Leu69Pro) variant of TNF (Tumor necrosis factor)
L69P (p.Leu69Pro) in TNF (Tumor necrosis factor) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.15 / 1. The record also includes population frequency data, published literature, and structural context.
L69P (p.Leu69Pro) variant details
- p.Leu69Pro
- gnomAD 6-31576553-T-C
- Missense
- Variant Prioritization Score for Impact Estimate 0.151
- REVEL 0.17
- CADD 9.53
- PolyPhen-2 0.00
- SIFT 0.21
- Most common in the South Asian population (allele frequency 1.2e-05)
- Structural context available
- Literature evidence available