L47I (p.Leu47Ile) variant of TNF (Tumor necrosis factor)
L47I (p.Leu47Ile) in TNF (Tumor necrosis factor) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.47 / 1. The record also includes population frequency data, published literature, and structural context.
L47I (p.Leu47Ile) variant details
- p.Leu47Ile
- gnomAD 6-31575880-C-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.467
- REVEL 0.37
- CADD 24.10
- PolyPhen-2 1.00
- SIFT 0.05
- Population evidence available
- Structural context available
- Literature evidence available