L33F (p.Leu33Phe) variant of TNF (Tumor necrosis factor)
L33F (p.Leu33Phe) in TNF (Tumor necrosis factor) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.41 / 1. The record also includes population frequency data and structural context.
L33F (p.Leu33Phe) variant details
- p.Leu33Phe
- ExAC rs747406665
- TOPMed rs747406665
- gnomAD rs747406665
- Missense
- Variant Prioritization Score for Impact Estimate 0.413
- REVEL 0.35
- CADD 20.80
- PolyPhen-2 0.22
- SIFT 0.02
- Most common in the Non-Finnish European population (allele frequency 2.7e-06)
- Structural context available