L31S (p.Leu31Ser) variant of TNF (Tumor necrosis factor)
L31S (p.Leu31Ser) in TNF (Tumor necrosis factor) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.48 / 1. The record also includes population frequency data and structural context.
L31S (p.Leu31Ser) variant details
- p.Leu31Ser
- gnomAD rs1771153168
- Missense
- Variant Prioritization Score for Impact Estimate 0.484
- REVEL 0.61
- CADD 15.00
- PolyPhen-2 0.68
- SIFT 0.00
- Most common in the Latino/Admixed American population (allele frequency 6.5e-05)
- Structural context available