L12M (p.Leu12Met) variant of TNF (Tumor necrosis factor)
L12M (p.Leu12Met) in TNF (Tumor necrosis factor) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.39 / 1. The record also includes population frequency data, published literature, and structural context.
L12M (p.Leu12Met) variant details
- p.Leu12Met
- gnomAD 6-31575775-C-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.39
- REVEL 0.36
- CADD 23.00
- PolyPhen-2 0.99
- SIFT 0.09
- Population evidence available
- Structural context available
- Literature evidence available