I7V (p.Ile7Val) variant of TNF (Tumor necrosis factor)
I7V (p.Ile7Val) in TNF (Tumor necrosis factor) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.43 / 1. The record also includes population frequency data, published literature, and structural context.
I7V (p.Ile7Val) variant details
- p.Ile7Val
- gnomAD 6-31575760-A-G
- Missense
- Variant Prioritization Score for Impact Estimate 0.428
- REVEL 0.31
- CADD 20.60
- PolyPhen-2 0.19
- SIFT 0.64
- Most common in the Middle Eastern population (allele frequency 0.00018)
- Structural context available
- Literature evidence available