I7T (p.Ile7Thr) variant of TNF (Tumor necrosis factor)
I7T (p.Ile7Thr) in TNF (Tumor necrosis factor) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.53 / 1. The record also includes population frequency data and structural context.
I7T (p.Ile7Thr) variant details
- p.Ile7Thr
- TOPMed rs1288613011
- gnomAD rs1288613011
- Missense
- Variant Prioritization Score for Impact Estimate 0.529
- REVEL 0.43
- CADD 27.60
- PolyPhen-2 0.94
- SIFT 0.00
- Most common in the African/African-American population (allele frequency 2.4e-05)
- Structural context available