I7F (p.Ile7Phe) variant of TNF (Tumor necrosis factor)
I7F (p.Ile7Phe) in TNF (Tumor necrosis factor) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.52 / 1. The record also includes population frequency data, published literature, and structural context.
I7F (p.Ile7Phe) variant details
- p.Ile7Phe
- gnomAD 6-31575760-A-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.515
- REVEL 0.41
- CADD 27.30
- PolyPhen-2 0.94
- SIFT 0.00
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available
- Literature evidence available