H52Y (p.His52Tyr) variant of TNF (Tumor necrosis factor)
H52Y (p.His52Tyr) in TNF (Tumor necrosis factor) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.47 / 1. The record also includes population frequency data and structural context.
H52Y (p.His52Tyr) variant details
- p.His52Tyr
- TOPMed rs3179060
- gnomAD rs3179060
- Missense
- Variant Prioritization Score for Impact Estimate 0.468
- REVEL 0.45
- CADD 23.00
- PolyPhen-2 0.05
- SIFT 0.04
- Most common in the Non-Finnish European population (allele frequency 1.5e-05)
- Structural context available