G57S (p.Gly57Ser) variant of TNF (Tumor necrosis factor)
G57S (p.Gly57Ser) in TNF (Tumor necrosis factor) is a missense change. Clinical records from ClinVar and UniProt describe it as uncertain significance in the context of not specified. The available variant effect predictions contribute to a CATVariant prioritization score of 0.67 / 1. The record also includes population frequency data and structural context.
G57S (p.Gly57Ser) variant details
- p.Gly57Ser
- rs777874746
- TOPMed rs777874746
- gnomAD rs777874746
- Uncertain significance
- not specified
- Missense
- Variant Prioritization Score for Impact Estimate 0.668
- REVEL 0.56
- CADD 29.50
- PolyPhen-2 0.99
- SIFT 0.03
- ClinVar: Uncertain significance (not specified)
- UniProt: Uncertain significance
- Most common in the Latino/Admixed American population (allele frequency 2.7e-05)
- Structural context available