G23E (p.Gly23Glu) variant of TNF (Tumor necrosis factor)
G23E (p.Gly23Glu) in TNF (Tumor necrosis factor) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.43 / 1. The record also includes population frequency data and structural context.
G23E (p.Gly23Glu) variant details
- p.Gly23Glu
- gnomAD rs1234547532
- Missense
- Variant Prioritization Score for Impact Estimate 0.429
- REVEL 0.25
- CADD 23.10
- PolyPhen-2 0.77
- SIFT 0.01
- Most common in the African/African-American population (allele frequency 2.4e-05)
- Structural context available