F38L (p.Phe38Leu) variant of TNF (Tumor necrosis factor)
F38L (p.Phe38Leu) in TNF (Tumor necrosis factor) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.58 / 1. The record also includes population frequency data and structural context.
F38L (p.Phe38Leu) variant details
- p.Phe38Leu
- ExAC rs757794184
- gnomAD rs757794184
- Missense
- Variant Prioritization Score for Impact Estimate 0.581
- REVEL 0.53
- CADD 27.00
- PolyPhen-2 0.92
- SIFT 0.01
- Most common in the Middle Eastern population (allele frequency 0.00017)
- Structural context available