E4Q (p.Glu4Gln) variant of TNF (Tumor necrosis factor)
E4Q (p.Glu4Gln) in TNF (Tumor necrosis factor) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.49 / 1. The record also includes population frequency data and structural context.
E4Q (p.Glu4Gln) variant details
- p.Glu4Gln
- Ensembl rs953747858
- Missense
- Variant Prioritization Score for Impact Estimate 0.488
- REVEL 0.40
- CADD 25.50
- PolyPhen-2 0.82
- SIFT 0.01
- Most common in the East Asian population (allele frequency 2.6e-05)
- Structural context available