E15Q (p.Glu15Gln) variant of TNF (Tumor necrosis factor)
E15Q (p.Glu15Gln) in TNF (Tumor necrosis factor) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.45 / 1. The record also includes population frequency data, published literature, and structural context.
E15Q (p.Glu15Gln) variant details
- p.Glu15Gln
- gnomAD 6-31575784-G-C
- Missense
- Variant Prioritization Score for Impact Estimate 0.448
- REVEL 0.38
- CADD 23.50
- PolyPhen-2 0.91
- SIFT 0.12
- Most common in the Non-Finnish European population (allele frequency 2.7e-06)
- Structural context available
- Literature evidence available