E15K (p.Glu15Lys) variant of TNF (Tumor necrosis factor)
E15K (p.Glu15Lys) in TNF (Tumor necrosis factor) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.42 / 1. The record also includes population frequency data and structural context.
E15K (p.Glu15Lys) variant details
- p.Glu15Lys
- Ensembl rs972459518
- Missense
- Variant Prioritization Score for Impact Estimate 0.424
- REVEL 0.34
- CADD 24.00
- PolyPhen-2 0.79
- SIFT 0.13
- Most common in the African/African-American population (allele frequency 2.4e-05)
- Structural context available