E14K (p.Glu14Lys) variant of TNF (Tumor necrosis factor)
E14K (p.Glu14Lys) in TNF (Tumor necrosis factor) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.49 / 1. The record also includes population frequency data and structural context.
E14K (p.Glu14Lys) variant details
- p.Glu14Lys
- ExAC rs775506502
- gnomAD rs775506502
- Missense
- Variant Prioritization Score for Impact Estimate 0.489
- REVEL 0.38
- CADD 22.60
- PolyPhen-2 0.29
- SIFT 0.27
- Most common in the African/African-American population (allele frequency 4.8e-05)
- Structural context available