D66N (p.Asp66Asn) variant of TNF (Tumor necrosis factor)
D66N (p.Asp66Asn) in TNF (Tumor necrosis factor) is a missense change. Clinical records from ClinVar and UniProt describe it as uncertain significance in the context of not specified. The available variant effect predictions contribute to a CATVariant prioritization score of 0.22 / 1. The record also includes population frequency data and structural context.
D66N (p.Asp66Asn) variant details
- p.Asp66Asn
- ExAC rs776692566
- TOPMed rs776692566
- gnomAD rs776692566
- Uncertain significance
- not specified
- Missense
- Variant Prioritization Score for Impact Estimate 0.216
- REVEL 0.18
- CADD 6.69
- PolyPhen-2 0.00
- SIFT 0.56
- ClinVar: Uncertain significance (not specified)
- UniProt: Uncertain significance
- Most common in the African/African-American population (allele frequency 2.4e-05)
- Structural context available