C49S (p.Cys49Ser) variant of TNF (Tumor necrosis factor)
C49S (p.Cys49Ser) in TNF (Tumor necrosis factor) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.65 / 1. The record also includes population frequency data and structural context.
C49S (p.Cys49Ser) variant details
- p.Cys49Ser
- gnomAD rs1771156812
- Missense
- Variant Prioritization Score for Impact Estimate 0.654
- REVEL 0.67
- CADD 25.20
- PolyPhen-2 0.87
- SIFT 0.02
- Most common in the East Asian population (allele frequency 0.00019)
- Structural context available