A74T (p.Ala74Thr) variant of TNF (Tumor necrosis factor)
A74T (p.Ala74Thr) in TNF (Tumor necrosis factor) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.24 / 1. The record also includes population frequency data and structural context.
A74T (p.Ala74Thr) variant details
- p.Ala74Thr
- TOPMed rs972350853
- gnomAD rs972350853
- Missense
- Variant Prioritization Score for Impact Estimate 0.245
- REVEL 0.16
- CADD 16.00
- PolyPhen-2 0.01
- SIFT 0.71
- Most common in the Latino/Admixed American population (allele frequency 4.5e-05)
- Structural context available