A44S (p.Ala44Ser) variant of TNF (Tumor necrosis factor)
A44S (p.Ala44Ser) in TNF (Tumor necrosis factor) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.56 / 1. The record also includes population frequency data, published literature, and structural context.
A44S (p.Ala44Ser) variant details
- p.Ala44Ser
- gnomAD 6-31575871-G-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.56
- REVEL 0.42
- CADD 23.20
- PolyPhen-2 0.65
- SIFT 0.10
- Most common in the South Asian population (allele frequency 1.2e-05)
- Structural context available
- Literature evidence available