A42T (p.Ala42Thr) variant of TNF (Tumor necrosis factor)
A42T (p.Ala42Thr) in TNF (Tumor necrosis factor) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.60 / 1. The record also includes population frequency data, published literature, and structural context.
A42T (p.Ala42Thr) variant details
- p.Ala42Thr
- gnomAD 6-31575865-G-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.595
- REVEL 0.55
- CADD 23.10
- PolyPhen-2 0.93
- SIFT 0.15
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available
- Literature evidence available