A42P (p.Ala42Pro) variant of TNF (Tumor necrosis factor)
A42P (p.Ala42Pro) in TNF (Tumor necrosis factor) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.65 / 1. The record also includes population frequency data and structural context.
A42P (p.Ala42Pro) variant details
- p.Ala42Pro
- gnomAD rs1312232547
- Missense
- Variant Prioritization Score for Impact Estimate 0.646
- REVEL 0.64
- CADD 24.40
- PolyPhen-2 0.97
- SIFT 0.03
- Most common in the Latino/Admixed American population (allele frequency 6.5e-05)
- Structural context available