T66I (p.Thr66Ile) variant of TLR9 (Toll-like receptor 9)
T66I (p.Thr66Ile) in TLR9 (Toll-like receptor 9) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.43 / 1. The record also includes population frequency data and structural context.
T66I (p.Thr66Ile) variant details
- p.Thr66Ile
- 1000Genomes rs189941642
- TOPMed rs189941642
- Missense
- Variant Prioritization Score for Impact Estimate 0.426
- REVEL 0.26
- CADD 22.90
- PolyPhen-2 0.99
- SIFT 0.19
- Most common in the 1KG:CHS population (allele frequency 0.0049)
- Structural context available