S69Y (p.Ser69Tyr) variant of TLR9 (Toll-like receptor 9)
S69Y (p.Ser69Tyr) in TLR9 (Toll-like receptor 9) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.33 / 1. The record also includes population frequency data and structural context.
S69Y (p.Ser69Tyr) variant details
- p.Ser69Tyr
- NCI-TCGA Cosmic COSV1005
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.326
- REVEL 0.27
- CADD 17.70
- PolyPhen-2 0.88
- SIFT 0.25
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the African/African-American population (allele frequency 6.1e-05)
- Structural context available