S69F (p.Ser69Phe) variant of TLR9 (Toll-like receptor 9)
S69F (p.Ser69Phe) in TLR9 (Toll-like receptor 9) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.31 / 1. The record also includes population frequency data and structural context.
S69F (p.Ser69Phe) variant details
- p.Ser69Phe
- rs1183785127
- NCI-TCGA Cosmic COSV1005
- gnomAD rs1183785127
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.31
- REVEL 0.23
- CADD 18.70
- PolyPhen-2 0.73
- SIFT 0.20
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the South Asian population (allele frequency 1.2e-05)
- Structural context available