S149Y (p.Ser149Tyr) variant of TLR9 (Toll-like receptor 9)
S149Y (p.Ser149Tyr) in TLR9 (Toll-like receptor 9) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.20 / 1. The record also includes population frequency data and structural context.
S149Y (p.Ser149Tyr) variant details
- p.Ser149Tyr
- ESP rs376087748
- ExAC rs376087748
- TOPMed rs376087748
- gnomAD rs376087748
- Missense
- Variant Prioritization Score for Impact Estimate 0.201
- REVEL 0.15
- CADD 15.60
- PolyPhen-2 0.07
- SIFT 0.02
- Most common in the African/African-American population (allele frequency 2.4e-05)
- Structural context available