S12P (p.Ser12Pro) variant of TLR9 (Toll-like receptor 9)
S12P (p.Ser12Pro) in TLR9 (Toll-like receptor 9) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.22 / 1. The record also includes population frequency data and structural context.
S12P (p.Ser12Pro) variant details
- p.Ser12Pro
- TOPMed rs1699598705
- Missense
- Variant Prioritization Score for Impact Estimate 0.217
- REVEL 0.15
- CADD 20.50
- PolyPhen-2 0.99
- SIFT 0.07
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available