R170C (p.Arg170Cys) variant of TLR9 (Toll-like receptor 9)
R170C (p.Arg170Cys) in TLR9 (Toll-like receptor 9) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.33 / 1. The record also includes population frequency data and structural context.
R170C (p.Arg170Cys) variant details
- p.Arg170Cys
- TOPMed rs1011356526
- gnomAD rs1011356526
- Missense
- Variant Prioritization Score for Impact Estimate 0.33
- REVEL 0.22
- CADD 23.90
- PolyPhen-2 0.81
- SIFT 0.00
- Most common in the Ashkenazi Jewish population (allele frequency 0.00029)
- Structural context available