P99L (p.Pro99Leu) variant of TLR9 (Toll-like receptor 9)
P99L (p.Pro99Leu) in TLR9 (Toll-like receptor 9) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.41 / 1. The record also includes population frequency data and structural context.
P99L (p.Pro99Leu) variant details
- p.Pro99Leu
- 1000Genomes rs5743844
- ESP rs5743844
- ExAC rs5743844
- TOPMed rs5743844
- Missense
- Variant Prioritization Score for Impact Estimate 0.415
- REVEL 0.17
- CADD 22.60
- PolyPhen-2 0.95
- SIFT 0.95
- Most common in the 1KG:CEU population (allele frequency 0.0042)
- Structural context available